Inside the nucleus Nrf2 activates the expression of antioxidant genes, including HO-1, NQO1, superoxide dismutase (SOD), and GPx
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As the inaugural JAK inhibitor authorized for autoimmune diseases, tofacitinib predominantly inhibits JAK1 and JAK3, exerts partial inhibitory activity against JAK2, and has a minimal impact on TYK2 [387, 388]
Clinical trials suggest that sulforaphane produces favorable results in cases where pharmaceutical products fail
Side effects of glutathione are not known as it does not lead to any lasting symptoms or cause medical concern due to its naturally occurring properties