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Potential Benefits of the Combination Complementary mechanisms

The psychogenic and addictive properties of cocaine are mediated, at least in part, through the blockade of DAT-mediated DA reuptake and an increase in extracellular DA

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Biomarkers of Alzheimer's include abnormal levels of betaamyloid and tau in blood and cerebrospinal fluid (CSF, the fluid surrounding the brain), the accumulation of betaamyloid and abnormal tau as seen on positron emission tomography (PET), decreased glucose metabolism as seen using PET and a compound called [ 18 F]fluorodeoxyglucose, brain atrophy as determined by structural magnetic resonance imaging (sMRI), and increased levels of the neurofilament light chain protein in CSF or blood, among others