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Introduction: Two Dominant Anabolic Research Pathways Skeletal muscle hypertrophy research is anchored around two primary mechanistic axes: the IGF-1/IGF-1R-PI3K-Akt-mTORC1 signalling cascade driving protein synthesis, and the myostatin-ActRIIB-SMAD2/3 pathway governing muscle mass ceiling (the brake on hypertrophic growth)

Abstract Oxidative stress, arising from an imbalance between reactive oxygen species (ROS) production and antioxidant defenses, is increasingly recognized as a pivotal driver of cancer initiation and progression

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