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Antioxidants for male subfertility (Cochrane review)

45 , 49484951, doi:10.1002/anie.200600771 (2006)

Integrated Research Applications AOD9604 started as a fat metabolism compound but has since opened up a second research direction in joint and cartilage biology: The bulk of AOD9604 research sits here

Mechanism of Action 5-Amino-1MQ exerts its metabolic effects primarily through competitive inhibition of nicotinamide N-methyltransferase (NNMT), an enzyme belonging to the methyltransferase superfamily that is expressed in multiple tissues including liver, adipose tissue, skeletal muscle, kidney, and brain, with particularly high expression in visceral (abdominal) adipose tissue - the fat depot most strongly associated with metabolic disease

doi: 10.1172/JCI9842