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Rammelt S, Illert T, Bierbaum S, Scharnweber D, Zwipp H, Schneiders W

Environ Sci Pollut Res 25(26):2662526642

Reactive oxygen species induce Cox-2 expression via TAK1 activation in synovial fibroblast cells

That is an issue because a dehydrated athlete will have more concentrated urine relative to a well-hydrated athlete, and so the concentration of any substances (prohibited or not) appearing in their urine will be higher, thus increasing the probability of an anti-doping rule violation being pursued against them simply because of their hydration status