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Deficiencies in B12 can directly lead to nerve damage and worsen symptoms of diabetic neuropathy.65 While most people can get adequate B12 through diet (meat, fish, dairy, fortified cereals), certain medications including metformin and proton pump inhibitors can impair absorption and raise the risk of deficiency

In 2008, French researchers found an association between glutathione depletion and heart failure

The synaptic function of the alpha-synuclein could also be disrupted by interfering with vesicle trafficking and the release of the neurotransmitter

Organization of the Rab-GDI/CHM superfamily: the functional basis for choroideremia disease