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What sets retatrutide apart is the dysesthesia side effect, which does not meaningfully occur with the other two medications

Additionally, bariatric surgery is a one-and-done procedure, so maintenance, when coupled with lifestyle changes, is easier to accomplish, as the weight-reducing change is permanent

Medicare does not currently cover GLP-1s for obesity, but recently announced that they will be among the drug classes which the federal government will aim to negotiate in 2025

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No, there are no FDA-approved generic versions of semaglutide available in the United States as of 2025