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Moreover, iPLA2, a member of the calcium-independent phospholipase A2 family, functions independently of glutathione by cleaving oxidized fatty acid chains from phospholipids, directly removing peroxidized products, effectively detoxifying damaged lipids, and maintaining membrane integrity (Chen et al., 2021)

IGF-1 has been implicated in the development of acne vulgaris by stimulating sebum production. The authors noted the study had limitations, including the fact that it only looked at formally diagnosed acne, which might miss milder cases

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