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In this case, 5-h-fasted mice were intraperitoneally administered with 0.75 U of insulin (Sigma-Aldrich, MO, USA) per kg body weight, and blood glucose concentrations were determined before (0) and at 15, 30, 60, and 120 min after insulin injection

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9 The current advantages, research stage and areas of opportunity of small molecule GLP-1RAs is summarized in Figure 3

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