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This weight loss is achieved through the medications action on GLP-1 receptors, which helps regulate hunger and caloric intake

A key pharmacological challenge in the drug's design is balancing glucagon receptor activity to avoid unwanted increases in hepatic glucose production and net hyperglycaemia, which would counteract the glucose-lowering effects of GLP-1 and GIP agonism

Other stimuli that enhance calcitonin secretion include supraphysiologic concentrations of glucagon (48), 5HT1 receptor agonists (49) gastrin (and pentagastrin) (50), alcohol (51), and exercise (52) and glucagon-like peptide-1 (GLP-1) (53) A detailed discussion of each of these stimuli is beyond the limits of this chapter and the reader is referred to a review on this subject for more detail (54) The finding that glucagon-like peptide-1 (GLP-1) agonists, an effective therapy for type 2 diabetes mellitus, bind to GLP-1 receptors, stimulates CT release and cause MTCs in rodents has stimulated a broad discussion regarding their safety in humans (53)

De Sales-Milln et al., 2024

As a result, it is not known whether those with pancreatitis should use Ozempic