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[146] [145] [159] Since both natural rewards and addictive drugs induce the expression of FosB (i.e., they cause the brain to produce more of it), chronic acquisition of these rewards can result in a similar pathological state of addiction

This study not only provides real-world cost-effectiveness findings that complement evidence from trial- or model-based CEAs but also summarizes up-to-date cost-effectiveness evidence, both of which are of importance for clinical decision-making regarding treatment selections and the formulation of healthcare reimbursement policies in real-world practice