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For those who require maximal weight loss, such as people managing severe obesity alongside cardiovascular risk or obstructive sleep apnoea, injectable therapy may remain the medically preferred route

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86,87 Differing from the effects observed in T2DM, the therapeutic efficacy of dulaglutide for MASLD is not particularly compelling based on current statistics

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This is why Tirzepatide (Mounjaro/Zepbound), which combines GLP-1 and GIP, produces better results than Semaglutide alone while causing less nausea (25% versus 44%)

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In addition, data on suicide risk in patients on incretin therapies may be confounded by underlying conditions, including obesity and diabetes, which have been linked to increased suicide risk

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