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Current evidence shows there is low risk of cross-reactivity between sulfonamide antimicrobial agents and sulfonamide non-antimicrobials

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J Allergy Clin Immunol 141(4):11691179 Peters MC, Mauger D, Ross KR, Phillips B, Gaston B, Cardet JC et al (2020) Evidence for exacerbation-Prone asthma and predictive biomarkers of exacerbation frequency

Thus, in addition to direct effects on oxidative phosphorylation, GR signaling downregulates HIF-1, leading to a suppression of glycolysis and impaired pro-inflammatory activation