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Note: All cited studies refer to in-vitro and animal model research

Liraglutide and tirzepatide are effective for weight loss but have a poorer safety profile and higher discontinuation rates due to adverse events

In the phase 2 trial of cagrilintide 2.4 mg co-administered with semaglutide 2.4 mg (CagriSema) in people with type 2 diabetes, the combination improved glycemic control and body weight relative to semaglutide alone, consistent with amylin adding a postprandial glucose-lowering contribution on top of GLP-1 action

doi: 10.1080/1028415X.2017.1421039

All steps described previously were carried out in a darkroom to prevent the interference of additional DNA damage