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Most patients side effects improve over time as their body gets used to the medication

Additionally, for the outcome of completed suicide, the generalizability of findings to the broader population of interest was limited (indirectness), as the evidence largely originated from studies involving overweight or obese patients with severe metabolic comorbidities

This effect is most pronounced during early treatment and may diminish with continued therapy

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By influencing both satiety pathways and brain reward systems, these therapies create meaningful changes in how individuals experience hunger and cravings