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Vitamin B12 is considered beneficial and generally safe, even at high doses

PHARMACOTHERAPY OF OBESITY Obesity is a state of sustained disequilibrium between energy intake and energy expenditure

While losing some lean mass during aggressive weight loss is expected, this ratio is favorable compared to diet-only approaches where lean mass losses can reach 30-40%

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The third is duration and safety : short controlled studies in animals say almost nothing about what months or years of exposure would do in a human, which is precisely why the cycling section defaults to scheduled off periods rather than open-ended use