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Healthcare providers play a crucial role in individualizing treatment approaches based on patient characteristics, preferences, and therapeutic goals, thereby optimizing the benefits of injectable therapies in combating the dual burden of obesity and diabetes

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Homocysteine is a sulfur-containing amino acid tightly involved in methionine metabolism

Collectively, these structural and dynamic insights establish a foundation for understanding the mechanisms underlying catalytic Thi4 function and provide a rationale for how mutations, such as D168G, improve Thi4 function in model organisms grown in aerobic conditions