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Here, we summarize that activation of GLP-1 receptor (GLP-1R) suppresses food intake and induces postsynaptic depolarization of membrane potential and/or presynaptic modulation of glutamatergic or GABAergic neurotransmission in brain nuclei located within the medulla oblongata, pons, mesencephalon, diencephalon, and telencephalon

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Furthermore, the apoptosis of SGNs detected by C-CASP3 immunostaining and western blot showed that there was much less C-CASP3-positive SGNs and remarkable reduction of the C-CASP3 protein levels in the NAC co-treated groups compared with the peroxynitrite-only groups, and it was also lower in the peroxynitrite + gpx1 / + NAC group compared with the peroxynitrite + gpx1 / group (Figures 7B,C)

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