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Effective contraception is essential during treatment, as these medications are contraindicated in pregnancy, with a recommended washout period (approximately 2 months for semaglutide) before planned conception

Zepbound (tirzepatide) is an FDA-approved prescription medication indicated for chronic weight management in adults with obesity (BMI 30 kg/m) or overweight (BMI 27 kg/m) with at least one weight-related comorbid condition

This drug blocks enzymes called Janus kinases (JAKs), which is thought to result in suppression of the pro-inflammatory action of several interleukins, including interleukin-6 (IL-6) (Migita 2014

PMID: 1465994

In: Wilkens K and Juneja V