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The abnormal architecture of the tumor vasculature results in hypoxia, immune exclusion, and poor drug delivery, thus promoting therapeutic resistance (128)
They also regulate tryptophan production, an amino acid that can boost melatonin levels, which in turn controls the circadian rhythm, improves sleep quality, and facilitates falling asleep
Preclinical studies in accelerated mouse models of diet-induced steatohepatitis have demonstrated that retatrutide improves steatohepatitis through mechanisms involving enhanced hepatic fat oxidation, reduced lipogenesis, decreased inflammation, and attenuation of fibrosis markers, supporting the rationale for clinical development in MASH [33]
Med 21 , 757 (2023)
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