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Clinical Manifestations The excessive intracellular calcium causes sustained muscle contraction and dramatically increases metabolic activity

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This is relevant in the framework of space nutrition, since faster uptake of amino acids leads to increased oxidation, protein catabolism, and amount of nitrogen excreted in urine 110

Metabolic surgery appears to lead to changes in levels of adipose tissue-derived microRNAs involved in obesity, insulin resistance, systemic inflammation, and the progression from pre-diabetes to type 2 diabetes, and these changes are correlated with clinical benefits (La Sala 2020