Classically, three metabolic alterations have been identified that contribute to the development of T2DM: 1) insulin resistance, 2) an eventual decrease in insulin secretion from pancreatic beta cells, and 3) an excess production of glucose from the liver
Since then, hundreds of preclinical studies have reported reduced intake, reward or relapse across a wide range of substances, including alcohol, nicotine, cocaine, amphetamines and opioids
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[DOI] [PubMed] [Google Scholar] 24.Alalwan A.A., Friedman J., Park H., Segal R., Brumback B., Hartzema A
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