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Obesity Science & Practice, 3 (1),3-14

In the Brain (Central Effects) Working on Brain Circuits GLP1 medicines dont just work in the stomachthey also act on parts of the brain that control hunger and reward

GLP-1 directly activates anorexigenic POMC and CART neurons and indirectly inhibits, via GABAergic transmission, orexigenic NPY and AgRP neurons [39]

The market is witnessing the emergence of more effective GLP-1s, with several new ones slated for release in 2026-2027, leading to an inevitable escalation of costs

In contrast, information regarding GIP secretion in response to BTR stimulation is limited (Table 2)