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Data were normalized to the geometric average of -actin, glyceraldehyde 3-phosphate dehydrogenase (GAPDH) and cyclophilin A and reported as fold changes compared to values obtained from the control group (set at 1.0)

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Notably, the combination of AOD9604 and HA appeared to offer greater benefits than either agent alone, suggesting a synergistic effect in promoting cartilage protection and repair [1]