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Yet (as reviewed here), selenoproteins are involved in the metabolism of thyroid hormones and can also scavenge reactive oxygen species (ROS), protecting against oxidative damage and inflammation

We observe a hydrophobic extracellular gate directly above the substrate-binding site, similar to that seen in OCT1, where residues of gating helices TM1 and TM7 pack together in both the occluded and inward conformations (e.g

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Importantly, tirzepatide carries a boxed warning and is contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)

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