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2007 Cai J, Nelson KC, Wu M, Sternberg P Jr, Jones DP

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Researchers have conducted a cross-sectional study among more than 3000 ordinary residents in Guangzhou, China, and the results showed that the severity of NAFLD was correlated with an increase in TMAO and betaine concentrations and a decrease in the betaine:choline ratio (Reference Dumas, Rothwell and Hoyles30)

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Unexpectedly, malonyl-CoA accumulated under these conditions (Figure 1F)