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Methionine's plasma half-life is approximately 34 hours, meaning the immediate methyl donation effect peaks within 68 hours post-injection

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In addition, the high incidence of postoperative issues was likely due to the inclusion of obsolete bariatric surgery procedures, as well as some patients with PWS-specific conditions (i.e., abnormal pain threshold, inability to vomit, predisposition to acute gastric dilatation, or more severe preoperative clinical conditions)

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