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In some embodiments, the osmolarity of any formulation or composition described herein is designed to be isotonic with the targeted otic structure (e.g., endolymph, perilymph or the like)

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Although BMSCs combined with calcium alginate composite gel injection therapy [146]and tissue-engineered slings incorporating BMSCs with biodegradable silk fabric scaffolds [147] have shown potential in treating SUI, their clinical applications have yet to be validated

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