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1830(5): p
The tool helps demonstrate exactly that
Membrane integrity is initially preserved, with regulated phosphatidylserine (PtdSer) exposure on the plasma membrane, mediated by scramblase [1]
IGF-1 LR3 carries an arginine substitution at position 3 and an N-terminal 13-amino-acid extension that reduces IGFBP affinity by roughly 1,000-fold, extending its active window to 20-30 hours
Together, those data indicate that arrestins are key partners of OR internalization but under specific conditions or agonist exposure, other arrestin-independent mechanisms could occur
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