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Furthermore, the increased solubility of CsA owing to the formation of a ternary complex with SBE--CD and SP played a pivotal role in increasing the availability of CsA at the ocular surface for absorption by acting as a carrier

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FIGURE 3 Moreover, a patent application has been filed by Magnani et al

More recent studies have reported additional mechanisms such as epigenome regulation, oxygen-sensing, immunomodulatory functions, epithelial-to-mesenchymal transition and kinase activity regulation [1, 2, 5, 60, 64, 99, 109, 217, 218] (Figs