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The effect of GLP-1R agonists liraglutide and exendin-4 was examined in vitro on LOVO, CA-77, MCF-7, MDA-MB-231, KPL-1, MB-468, 4TI, BT483, ZR751, LNCap, PC3, ALVA-41, DU145, LNCap, PANC-1, MiaPaCa-2, PANC, CT26, SKOV3, OVCAR3, OVCAR4, A2780, and ES-2 cell lines that are expressed in several cancers including colorectal, pancreatic, thyroid, breast, prostate, ovarian, and colon (Table 1)
But how accurate are these tests, and are the results useful
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In rare cases, it may lead to low blood pressure or an increased heart rate
Retatrutide's ~6-day half-life means that a 5-day dosing interval would administer the next dose before the drug has reached one half-life resulting in higher trough levels and faster accumulation to steady state
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