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Following 40 min of access, mice were treated as indicated (acyl-GIP at 100 nmol kg 1 , PYY at 100 nmol kg 1 (Bachem 4018880), acyl-GIP + PYY or LiCl at 0.2 M (Sigma 7447-41-8) or VEH (PBS containing 0.05% Tween80))

Through the application of PTE and Patent Term Adjustment (PTA), Novo Nordisk succeeded in pushing the expiration of the 343 patent to December 5, 2031

Administration is straightforward

For weight management, NICE provides guidance on eligibility for specialist weight management services, which may include other pharmacological options such as orlistat (though this can also cause gastrointestinal side effects that may be problematic in IBD)