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KEGG pathway enrichment analysis statistically evaluates whether a set of genes or proteins is over-represented in specific pathways compared with a background distribution, highlighting biological systems significantly impacted under experimental conditions

10.1371/journal.pone.0063197 [DOI] [PMC free article] [PubMed] [Google Scholar] 25.Marini A, Grether-Beck S, Jaenicke T, Weber M, Burki C, Formann P, et al

Stock solutions A stock solutions of 0.1 mol/L N-Hcy-Lys and 0.05 mol/L Cys, Hcy, GSH were prepared in 1 mol/L and 0.1 mol/L HCl, respectively

Very high doses of B12 taken orally may occasionally cause mild gastrointestinal disturbance in some individuals, though this is uncommon

As shown in Table 1, the enrollment was age- and sex-matched because there were no significant differences in age and gender distribution between the patients and the healthy control groups