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Its a choice that reflects a deliberate strategy to achieve a specific pharmacokinetic profile suitable for studying the slow, steady processes of metabolism

GLP-1 is produced by l-cells primarily in the distal parts of the intestine, but it can also activate a Gs-coupled GLP-1 receptor (GLP-1R) resulting in proliferation of human coronary artery endothelial cells as well as -cells in pancreas (Egholm et al., 2016)

J Med Case Rep (2009) 3:11

Although indirect comparisons suggest that SGLT2 inhibitors may offer greater protection against kidney function decline, direct head-to-head trials are lacking

Skouta et al., 2014