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The metabolomic analysis revealed that the primary significantly enriched metabolic pathways in both the PD and normal control (NC) groups included glucose signaling, central carbon metabolism, the tricarboxylic acid (TCA) cycle, glycolysis, choline metabolism, and fatty acid metabolism

In another study, a high dose of rapamycin was able to extend the lifespan of mice by 24% (males) and 26% (females) [19]

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However, semaglutide products are already approved for specific uses, while retatrutide remains investigational