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Lack of Clinical Evidence Critical gaps in knowledge: Zero randomized controlled trials on microdosing GLP-1 agonists No long-term safety data for alternative dosing regimens Unknown effects on cardiovascular outcomes Potential for reduced efficacy not captured in models 3

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A second row makes a related point about insulin-resistant individuals, who it says typically experience greater improvement in triglyceride profiles as insulin sensitivity recovers with weight loss and medication effects

This new collection is available now at www.patchmd.com/glp-1-patches.html

In the COR (Contrave Obesity Research) clinical trials, average weight loss was about 5-8% of body weight over 56 weeks