Alex Fishman, brand director at Pure Protein, added: As the dietary supplement market in the US becomes increasingly more congested and expensive, users and especially those taking GLP-1 medications are seeking simplified, yet effective solutions to help them achieve their health and fitness goals
Commissioner Makary stated: "Compounded drugs can be important for overcoming shortages or meeting unique patient needs, but compounders should not try to compound drugs in a way that circumvents FDA's approval process." While these targeted injectables, not herbal patches, the regulatory direction is clear
GLP-1RAs reduce HbA1c by 0.8%1.5% points in people living with T2D and 0.3% points in people with obesity without T2D, depending on baseline levels (48, 49, 59, 6971)
The common link is that GLP-1s activate receptors that then work on driving down metabolic risk factors through the following mechanisms: Enhancing glucose dependent insulin secretion Slowing gastric emptying and decreasing appetite Reducing postprandial glucagon and food intake UpToDate 2 : (1) ingestion of food results in (2) release of gastrointestinal peptides (GLP-1 and GIP: glucose-dependent insulinotropic polypeptide, gastric inhibitory peptide) and (3) pancreatic beta cell hormones (insulin and amylin)
In 2024, a 3-month pilot program evaluated whether initial outreach by postal mail affected enrollment among groups with low enrollment rates: those of Hispanic/Latino ethnicity and those without email addresses
