Dehydrating side effects, particularly diarrhea and vomiting, may enhance this risk
GLP-1 and GIP receptors are found in the brain, alongside fat cells, pancreatic beta cells and other tissues involved in metabolism
When GIP receptors activate in fat tissue, they appear to promote what researchers call fat cell browning, a process where white adipose tissue takes on characteristics of metabolically active brown fat
Additionally, GLP-1 therapies suppress glucagon, a hormone that normally elevates blood sugar, further enhancing glucose regulation
Commonly reported retatrutide side effects in trials include: Nausea (especially during dose increases) Vomiting Diarrhoea or constipation Abdominal pain or bloating Indigestion / reflux Injection-site reactions or hypersensitivity in some people So far, hair loss has not been listed as a common, direct side effect of retatrutide in clinical trial publications