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Intervention groups received either GLP1RAs monotherapy or GLP1RAs plus metformin combined therapy, whilst patients in control groups used placebo or metformin alone

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Hydration levels are also very important, as thirst signals could be mistaken for hunger

Why Biological Intervention Matters : According to obesity medicine research published in peer-reviewed journals, traditional behavioral weight loss interventions (diet and exercise alone) typically achieve only 2-4% body weight reduction, with 80-95% of individuals regaining lost weight within 1-5 years due to powerful biological adaptations including: Metabolic rate reduction (adaptive thermogenesis) Hunger hormone dysregulation (increased ghrelin, decreased leptin) Increased appetite and food preoccupation Reduced satiety signaling Enhanced calorie absorption efficiency Decreased energy expenditure during physical activity These biological adaptations explain why "eat less, move more" advice, while physiologically accurate, proves insufficient for most individuals struggling with obesity-their bodies actively resist sustained weight loss through multiple redundant biological mechanisms