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Biol Psychiatry (2012) 71:95661.10.1016/j.biopsych.2012.01.014 73 GhanizadehAMoghimi-SaraniE

While weight loss drugs can provide initial benefits in terms of appetite suppression and initial weight reduction, their long-term effectiveness may vary

They also promote more pronounced growth hormone pulses compared to GHRH analogs

Taken together, these findings suggest that IGF-1-mediated regulation of protein metabolism in humans cannot be excluded as a possible mechanism, although LC supplementation may affect muscle protein balance in people with low circulating IGF-1 level

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