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Systematic reviews indicate that citrulline can reduce both brachial and aortic systolic pressures in pre-hypertensive individuals, yet inter-patient variability necessitates vigilant monitoring during infusion therapy

Approach Standard cycle Length 812 weeks Off period 46 weeks Common use Most common maintenance pattern

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No one in the GLP-1 group experienced significant gastrointestinal adverse events during the study, and none discontinued GLP-1 use