Also, reversed was increased number of inflammatory cells (38, 44-46) and raised leukotriene B4 (LTB4), thromboxane B2 (TXB2), and myeloperoxidase (MPO) in the serum and inflamed tissues (47-49)
Our results indicated that neither GHK nor GHK-Cu showed cytotoxic activity at the range of concentrations tested while CuCl 2 and Cu(OAc) 2 showed substantial cytotoxicity to the HaCaT cells at the highest concentration assayed, i.e., at 5800 M, after 30 mins treatment
instead, research points to interactions with the nitric oxide (NO) system, growth factor receptor upregulation, and modulation of several cytokine pathways
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