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In particular, the beneficial effects of GLP1 have been combined in dual agonists (for both GLP1 and GIP receptors or GLP1 and glucagon receptors) or triagonist (for GLP1, GIP and glucagon receptors) strategies (Capozzi et al., 2018

It was originally isolated on the basis of inhibitory effects on acid secretion in canine isolated gastric pouches, but this effect could not be reproduced under physiological circumstances in humans (21), and gradually the meaning of the acronym (GIP): Gastric Inhibitory Peptide, changed to glucose-dependent insulinotropic polypeptide

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