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Sci Rep 15(1):21627 CB Filho JC, Donato F, Giacomeli R, Del Fabbro L, da Silva Antunes M, De Gomes MG, Goes AT, Boeira SP, Prigol M, Souza LC (2015) Chronic unpredictable mild stress decreases BDNF and NGF levels and Na (+), K (+)-ATPase activity in the hippocampus and prefrontal cortex of mice: antidepressant effect of chrysin

It also speeds up cell renewal and improves blood flow within the skin, helping injuries heal faster

They allow researchers to observe whether a molecule that works in a dish also works when applied to a complete biological system with its own circulatory, immune, and signaling networks

Results can vary widely

A separate study addressing oxidative stress mechanisms, Pickart et al