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Nuclei were stained with 200 nM 4,6-diamidino-2-phenyl-indole (DAPI) for 5 min

Trial data describe pharmaceutical-grade material under monitoring

and glutathione synthetase (GSS) [7, 8]

The dense fibrous capsule that characterizes mature tophi forms the structural core of this process and originates from sustained fibroblast activation and phenotypic transformation driven by the chronic inflammatory microenvironment (173)

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