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Reference Traber MG, Elsner A, Brigelius-Floh R

Nitric Oxide System Modulation One of BPC-157's most important mechanisms involves the nitric oxide (NO) system

Other environmental factors can further lower glutathione levels, such as stress and poor nutrition (x)

NSAIDs also have harmful effects on the liver, kidneys, GI tract and cardiovascular system, while steroids can affect blood sugar levels and cause weight gain, exacerbating metabolic issues that contribute to knee OA

This is particularly concerning in light of evidence showing low enrollment of individuals from minority groups in clinical trials and the resulting lack of population-specific data (189)