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It was reported that BMAL1 deficient mice had altered circadian rhythm of circulating IGF-1 levels (Patel et al., 2016), and CRY1 and 2 deficient mice had reduced IGF-1 production ( Due to the difficulty in measuring pulsatile GH secretion, the interaction between the GH-IGF-1 axis and circadian clock warrants further detailed research

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By 2035, the market is projected to reach an index value of 385 (2025=100), reflecting a compound annual growth rate of 12.8% over the 2026-2035 forecast horizon