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A 2023 analysis of GLP-1 clinical trials found that approximately 30-40% of weight loss occurred through metabolic changes independent of calorie reduction, while 60-70% came from eating lessdemonstrating that appetite suppression alone does not explain the full effect

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There is no absolute contraindication to combining GLP-1 medications with Hashimoto's disease, provided hypothyroidism is adequately managed with levothyroxine replacement

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