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Previous studies have indicated that intestinal iron overload, such as that induced by ferric citrate, damages epithelial villi and goblet cells, leading to reduced expression of tight junction proteins [21]

10.1016/j.ijcard.2024.13252739244097 123 Wang J, Zhou J, Shao Z, et al

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Phase I detoxification uses cytochrome P450 enzymes to break down toxins, but this process often creates highly reactive, intermediate metabolites that are actually more toxic than the original substance

Glutathione levels are lowest in the mornings, which is why many suggest using glutathione supplementation before bed or first thing in the morning