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Structural Differences IGFDES is IGF1 missing the first 3 amino acids (DES(1-3)) IGF1 LR3 is a long-chain version of IGF1 with 13 additional amino acids at the N-terminal These structural modifications change how they interact with IGF binding proteins (IGFBPs) and how long they remain active in the body

Biased agonism values (log (/K A )) and their error were calculated using the agonist relative efficacy and by making between pathway comparisons for an agonist relative to a reference signaling molecule, cAMP (van der Westhuizen et al., 2014)

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